1. 4

    ” the chorea that Michael J Fox has in that ad comes from chronic use of dopamine agonists in the context of Parkinson’s. They’re movements from the medicine, not the disease itself. Although he might have odd movements OFF of his meds, they wouldn’t look like the ones in the ad. They’d look like the Parkinson’s-like presentation of Muhammed Ali’s Dementia Pugilistica.

    In addition, those movements are hard to imitate accurately because they stem from circuits between the basal ganglia and cortex that you can’t just turn off or on. Those aren’t volitional circuits. There is little chance he was acting, and if he was, he could only accentuate slightly movementse already had. In other words, this is as tragic as it looks.”